The cRhona application is a “clone” of an evidence intermediary, integrating the latest Artificial Intelligence technologies to amplify its efficiency, accuracy, collaboration, coordination, and transparency in rapid evidence synthesis approaches. In the cRhona application, policymakers, evidence intermediaries, and domain experts collaborate and coordinate to ensure that the evidence synthesis is just-in-time when it is needed, comprehensive and high quality even in very urgent situations, e.g., less than 48 hours.